Dec 04, 2018 chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from lowgrade tumors with low metastatic potential to highgrade, aggressive tumors characterized by early metastasis. Chondrosarcoma hxbenefit recent health articles and news. Radiation oncologysarcomachondrosarcoma wikibooks, open. Usually a good prognosis 75% five year survival in one large data set. It is the second most common primary malignancy of bone, and one of the most. Whether you or someone you love has cancer, knowing what to expect can help you cope. Files are available under licenses specified on their description page. Pdf dedifferentiated chondrosarcoma laura campanacci.
Chondrosarcoma is a malignant bone tumor arising from cartilaginous tissue, most frequently occuring at the ends of the femur and tibia, the proximal end of the humerus and the pelvis. Chondrosarcoma can appear in any part of the body where cartilage is present. Chondrosarcoma is located here less often than the femur. Mesenchymal chondrosarcoma is a malignant cancerous type of chondrosarcoma, or cancer of cartilage connective tissue. Multiple cartilaginous exostoses and development of. The pelvis, ribs, femur, and humerus are the most frequently affected sites, and scapula involvement is. It develops from normal cartilage which goes through malignant change or can form within a preexisting benign tumor. Chondrosarcoma treatment, pictures, symptoms, causes. The two components are juxtaposed with abrupt clear demarcation line. There are currently no approved chemotherapy options for this disease and, when surgery is not possible, chondrosarcoma is. Extraskeletal myxoid chondrosarcoma emcs is a rare soft tissue sarcoma of uncertain differentiation, characterized in most cases by a translocation that results in the fusion protein ewsr1chn the latter even called nr4a3 or tec. It represents about 25% of all bone sarcomata and typically occurs in adults aged between 30 and 60 years.
Symptom of hyoid chondrosarcoma are poor in specificity. The symptoms associated with chondrosarcoma can vary from person to person depending on where their tumor is located and the size of the tumor. Apr 10, 2009 chondrosarcoma accounts for about a quarter of all bone cancers, which makes it the second most common type of bone cancer. Chondrosarcoma of the temporomandibular joint med oral patol oral cir bucal. During skeletal growth, the osteochondromas are benign, but in adult life malignant transformation into chondrosarcomas can occur. Chondrosarcoma is a type of cancer closely related to bone cancer. Dedifferentiated chondrosarcoma consists of a low grade malignant hyaline cartilage tumor associated with a highgrade nonchondroid spindle sarcoma. Chondrosarcoma chs is a malignant cartilageforming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Dedifferentiated chondrosarcomas arising in preexisting osteochondromas article in the journal of bone and joint surgery 895. People who have chondrosarcoma have a single tumor growth which can vary in size and location when first discovered. The symptoms of this disorder can vary from one patient to another.
The factors that influence local and systemic control of pelvic cs and the functional outcome should be evaluated. Dedifferentiated chondrosarcoma portnotes orthopaedicsone. This cancer can also occur in animals such as cats and dogs. A core biopsy can be used to help distinguish this tumor from other, less. However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the ends of bones and lines joints, not in the bone tissue itself. Pathology they tend to be of higher grade than runofthemill conventional intramedullary chondrosarcomas, with the majority being of t. Currently awaiting final results to tell me how bad the cancer is. Chondrosarcoma can affect people of all ages but is mostly found in adults between the ages of 30 and 60 years. This report presents clinicopathologic, radiographic, and immunohistochemical features of an unusual dedifferen tiated chondrosarcoma with a gastrointestinal stromal tu. Jul 01, 2015 chondrosarcoma is a malignant bone tumor arising from cartilaginous tissue, most frequently occuring at the ends of the femur and tibia, the proximal end of the humerus and the pelvis. Chondrosarcomas can develop in any place where there is cartilage. Unlike other primary bone cancers that mainly affect children and adolescents, chondrosarcoma can present at any age. In type 1, the radiographic appearance is the same as for a central chondrosarcoma, with the addition of a region with very aggressive bone destruction. Chondrosarcoma is a malignant mesenchymal tumor originating from cartilage.
Chondrosarcoma is described as either localized or metastatic. Treating specific bone cancers american cancer society. However, in a previous report, 2 out of patients with dedifferentiated chondrosarcoma experienced a good response to chemotherapy, demonstrating more than 90% necrosis. Anatomically, the femur, pelvis and humerus are the most common sites of involvement. It arises most frequently in the 5th and 6th decade of life. Chondrosarcomas are malignant cartilaginous tumors that account for 25% of all primary malignant bone tumors.
Middleaged to elderly individuals are most prone to this tumor formation. Conventional tumors are divided by location into central, peripheral and juxtacortical periosteal forms tumors often recur at a higher histologic grade poorly differentiated tumors are uncommon, recur locally due to satellite nodules. Mesenchymal chondrosarcoma oxford university hospitals. It is different from other more common bone cancers like osteosarcoma, which arise from bone cells.
Pdf merge combinejoin pdf files online for free soda pdf. It is the second most common primary malignancy of bone, and one of the most difficult bone tumors to diagnose and treat. Full text get a printable copy pdf file of the complete article 1. Chondrosarcoma of the temporomandibular joint e43 of the condylar neck, and radiopacity of the condyle can be seen. Chondrosarcoma is a type of sarcoma that affects the bones and joints.
Dedifferentiated chondrosarcoma occurs in approximately 11% of patients diagnosed with chondrosarcoma and is considered to be a histological subtype of this chondroid lesion. Bone cancer surgery is the main form of treatment for chondrosarcoma. It is a rare cancer that accounts for about 20% of bone tumors and is diagnosed in approximately 600 patients each year in the united states. Chondrosarcoma grades iiii, including primary and secondary variants and periosteal chondrosarcoma.
A slow growing painless mass in the neck is a common sign. There may be one or more areas of cancer in the bone that can be removed during surgery. About 30% of skeletal system cancers are chondrosarcomas. Chondrosarcoma can be located in any of the vertebrae from the neck all the way down to the tail bone. Get a printable copy pdf file of the complete article 5. Chondrosarcoma genetic and rare diseases information center. Had partial hip and full femur replacement, am doing okay with walking frame, i would find crutches hard to manage, hope to graduate to walking. Chondrosarcoma with intravascular growth and tumor emboli to lungs. If the tumor is highgrade, limbsparing surgery will be done if possible. Chondrosarcoma can be located in any of the vertebrae from the. Dec 10, 2012 however, in a previous report, 2 out of patients with dedifferentiated chondrosarcoma experienced a good response to chemotherapy, demonstrating more than 90% necrosis. An external file that holds a picture, illustration, etc.
Dedifferentiated chondrosarcomas consist of two distinguishable components. What links here related changes upload file special pages permanent link page. Media in category chondrosarcoma the following 6 files are in this category, out of 6 total. Enchondromatosis or olliers disease is another risk factor for the disorder. Emcs is marked by 40% incidence of metastases in spite of its indolent behaviour. Mesenchymal chondrosarcoma of the mandible figure 1. Case report primary intraosseous myxoid chondrosarcoma arising. Subtypes vary substantially chondrosarcoma nos and myxoid chondrosarcoma have a five year survival of 70%, but mesenchymal chondrosarcoma only 50%, and dedifferentiated chondrosarcoma an abysmal 0%. The high grade sarcoma is most commonly an mfh, osteosarcoma or fibrosarcoma although others may occur. Grade and stage are independent predictors of survival. Chondrosarcoma is ranked the second most frequent bone cancer with osteosarcoma another similar cancer being the most common.
Dedifferentiated chondrosarcomas arising in preexisting. In the mandible the most common location is the premolarmolar area but the symphysis or. Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from lowgrade tumors with low metastatic potential to highgrade, aggressive tumors characterized by early metastasis. Chondrosarcoma is the most common form of primary bone cancer affecting all age groups. Chondrosarcoma genetic and rare diseases information. The typical presentation is in the 4 th and 5 th decades and there is a slight male predominance of 1. Netherlands, 1998 pmid 9667567 intracranial chondrosarcoma. Soda pdf merge tool allows you to combine two or more documents into a single pdf file for free. Chondrosarcoma is a malignant tumor with cells that produce cartilage matrix. Find out about the symptoms, causes, and treatment of chondrosarcoma, a type of bone cancer most common in your pelvis, thighbone, or upper arm.
People who have chondrosarcoma have a tumor growth starting from the medullary canal of a long. In the uk there are around 190 new cases of chondrosarcoma diagnosed each year. Chondrosarcoma treatment the plan of treatment will depend on how aggressive the tumors are, the grade of the tumor, the size of the tumor, and where they are located. World health organization classification of tumours of soft tissue and bone, 4th ed, fletcher cdm, bridge ja, hogendoorn pcw, mertens f eds, iarc, lyon 20. Extraskeletal chondrosarcoma radiology reference article. Three radiographic types of dedifferentiated chondrosarcoma have been described. Review article primary chondrosarcoma of the hyoid bone. Extra skeletal myxoid chondrosarcomas typically occur in the extremities, with the thigh being most common. It is generally resistant to conventional chemotherapy, and, to the best of our. Unlike other primary bone cancers that mainly affect children and adolescents. Extraskeletal myxoid chondrosarcoma emc is an infrequent, lowgrade tumor of the soft tissues, forming around bones. The condition is classified into several categories depending on the appearance of the tumor under the microscope. Hi, im bindi, recently diagnosed with chondrosarcoma in left thigh.
Chondrosarcoma is a rare type of malignant tumor that begins in cartilage cells and spreads to the surrounding bone tissue. Rearrange individual pages or entire files in the desired order. Grimer rj1, gosheger g, taminiau a, biau d, matejovsky z, kollender y, sanjulian m, gherlinzoni f, ferrari c. Localized chondrosarcoma has not spread out of the bone where the cancer started. Having tenderness in the area affect, a lump on the bone, or swelling in your joints. These results suggest a possible benefit of chemotherapy for some patients with dedifferentiated chondrosarcoma. Chondrosarcoma defination malignant tumour of cartilage producing cells 4. Chondrosarcoma is a bone sarcoma that develops in the cartilage cells.
Round cells with abundant clear cytoplasm distinct cytoplasmic borders with a background of cartilaginous matrix. Pathology they tend to be of higher grade than runofthemill conventional intramedullary chondrosarcomas, with the majority being of the myxoid most common or mesenchymal varieties 3 location. After age 20, the risk of getting a chondrosarcoma goes up until about age 75. Reviewed all cases of intracranial chondrosarcoma in the netherlands and available data in the literature. Mesenchymal chondrosarcoma highgrade tumor small round blue cells islands of benignappearing cartilage. Nine cases 4 males, 5 females of dedifferentiated chondrosarcoma were treated in our institute. Fine needle aspiration cytology of a metastatic skin nodule diagnosed as a dedifferentiated chondrosarcoma. Most of the time, chondrosarcoma shows up in the thigh bone, upper arm bone, shoulders, ribs, or pelvis. Oct 04, 2016 histological subtypes clear cell chondrosarcoma mesenchymal chondrosarcoma dedifferentiated chondrosarcoma 18. They occur at all ages but typically around the age of 50 3. A unique case of dedifferentiated chondrosarcoma arising solely within the orbit is presented. Clear cell chondrosarcoma has a strong tendency to arise in an epiphysis benign radiographic features and can be confused with chondroblastoma or giant cell tumor. Doctor has suggested complete hip and femur replacement.
Treatment once chondrosarcoma has been diagnosed, there are several options available for treatment, including. In grade ii chondrosarcoma, higher nuclear survivin was seen in p53 overexpressing chondrosarcomas, as well as in grade iii chondrosarcoma p o0. For a lowgrade chondrosarcoma in an arm or leg, curettage with cryotherapy is an option. Chondrosarcoma cs most commonly involves the pelvis.
Osteoblasts then migrate into this matrix and initiate ossification. Dedifferentiated chondrosarcoma is an uncommon malignant cartilaginous neoplasm of bone characterized by the presence of a malignant spindle cell neoplasm associated with a low or mediumgrade. Dedifferentiated chondrosarcoma accounts for approximately 10% of all chondrosarcomas and shows an increased growth rate and rapid metastatic spread in comparison with ordinary chondrosarcomas. Chondrosarcoma is usually slow growing at low histological grades and can be well managed by. Extraskeletal chondrosarcomas make up only 2% of softtissue sarcomas and only 1% of all chondrosarcomas. The trial, which is the first of its kind to be done in chondrosarcoma, is expected to enroll more than 100 patients.
Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage. Rare subtypes of chondrosarcoma, including dedifferentiated, mesenchymal, and. Radiographically, there is often an abrupt transition between these tissue types within the lesion. After a biopsy confirms the diagnosis, surgery is done to remove the tumor. From basic information about cancer and its causes to indepth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here.
It doesnt happen often, but you can get it in the muscles, nerves, and other soft tissue. Again, the upper parts of these bones are called the proximal and the lower part is called the distal. This is a primary cancer with no apparent spread but understand can spread very quickly to lungs. Patients usually present with pain, pathological fracture, a palpable lump or local mass effect. Chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine. The term chondrosarcoma is used to define an heterogeneous group of lesions with diverse features and clinical behavior. Chondrosarcoma is a malignant cancer that results in abnormal bone and cartilage growth. Dedifferentiated chondrosarcoma arising in the orbit. The tumor location was the long bone in 7 cases femur, n5.
Again, its important that the biopsy be done by the same surgeon who will remove the tumor. The rare hereditary diseases such as maffuccis syndrome and multiple exostoses hme may also increase the risk of developing chondrosarcoma. Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce. Types defination cf frequency radiology epidemiology histology etiology 4. Chondrosarcoma is a malignant tumor composed of cartilageproducing cells. The clinical approach towards chondrosarcoma the oncologist. The disease usually starts in the bones of the arms, legs or pelvis. Specifically, for tmj chondrosarcoma, radiographic. Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. Because of their rarity persons with this type of cancer will need to be treated at specialty hospitals that have sarcoma centers.
Chondrosarcoma is the most common sarcoma of bone in patients over 20 years of age, with an annual agespecific incidence of 1. People who have chondrosarcoma have a tumor growth starting from the medullary canal of a long and flat bone. Chondrosarcoma symptoms, prognosis, treatment, survival. Clinical outcome for patients with dedifferentiated. Dedifferentiated chondrosarcoma is an aggressive subtype of chondrosarcoma that is characterized by a cartilaginous component and a highly lytic sarcomatous component. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
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